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Effectiveness of pertussis vaccination and duration of immunity

Overview of attention for article published in CMAJ, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
21 news outlets
blogs
3 blogs
policy
1 policy source
twitter
97 tweeters
facebook
6 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
75 Mendeley
Title
Effectiveness of pertussis vaccination and duration of immunity
Published in
CMAJ, September 2016
DOI 10.1503/cmaj.160193
Pubmed ID
Authors

Kevin L. Schwartz, Jeffrey C. Kwong, Shelley L. Deeks, Michael A. Campitelli, Frances B. Jamieson, Alex Marchand-Austin, Therese A. Stukel, Laura Rosella, Nick Daneman, Shelly Bolotin, Steven J. Drews, Heather Rilkoff, Natasha S. Crowcroft

Abstract

A resurgence of pertussis cases among both vaccinated and unvaccinated people raises questions about vaccine effectiveness over time. Our objective was to study the effectiveness of the pertussis vaccine and characterize the effect of waning immunity and whole-cell vaccine priming. We used the test-negative design, a nested case-control study with test-negative individuals as controls. We constructed multivariable logistic regression models to estimate odds ratios (ORs). Vaccine effectiveness was calculated as (1 - OR) × 100. We assessed waning immunity by calculating the odds of developing pertussis per year since last vaccination and evaluated the relative effectiveness of priming with acellular versus whole-cell vaccine. Between Dec. 7, 2009, and Mar. 31, 2013, data on 5867 individuals (486 test-positive cases and 5381 test-negative controls) were available for analysis. Adjusted vaccine effectiveness was 80% (95% confidence interval [CI] 71% to 86%) at 15-364 days, 84% (95% CI 77% to 89%) at 1-3 years, 62% (95% CI 42% to 75%) at 4-7 years and 41% (95% CI 0% to 66%) at 8 or more years since last vaccination. We observed waning immunity with the acellular vaccine, with an adjusted OR for pertussis infection of 1.27 (95% CI 1.20 to 1.34) per year since last vaccination. Acellular, versus whole-cell, vaccine priming was associated with an increased odds of pertussis (adjusted OR 2.15, 95% CI 1.30 to 3.57). We observed high early effectiveness of the pertussis vaccine that rapidly declined as time since last vaccination surpassed 4 years, particularly with acellular vaccine priming. Considering whole-cell vaccine priming and/or boosters in pregnancy to optimize pertussis control may be prudent.

Twitter Demographics

The data shown below were collected from the profiles of 97 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Australia 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 17%
Student > Master 13 17%
Student > Bachelor 8 11%
Researcher 7 9%
Student > Doctoral Student 6 8%
Other 15 20%
Unknown 13 17%
Readers by discipline Count As %
Medicine and Dentistry 23 31%
Immunology and Microbiology 6 8%
Agricultural and Biological Sciences 5 7%
Biochemistry, Genetics and Molecular Biology 5 7%
Mathematics 3 4%
Other 7 9%
Unknown 26 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 249. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2020.
All research outputs
#57,573
of 14,538,182 outputs
Outputs from CMAJ
#134
of 6,623 outputs
Outputs of similar age
#2,358
of 266,829 outputs
Outputs of similar age from CMAJ
#6
of 103 outputs
Altmetric has tracked 14,538,182 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,623 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.