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CMAJ

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Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children

Overview of attention for article published in CMAJ, September 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 5,696)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
121 news outlets
blogs
10 blogs
twitter
284 tweeters
facebook
24 Facebook pages
googleplus
4 Google+ users
reddit
13 Redditors
video
1 video uploader

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
45 Mendeley
Title
Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children
Published in
CMAJ, September 2018
DOI 10.1503/cmaj.170809
Pubmed ID
Authors

Mon H. Tun, Hein M. Tun, Justin J. Mahoney, Theodore B. Konya, David S. Guttman, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Malcolm R. Sears, Jeffrey R. Brook, Wendy Lou, Tim K. Takaro, James A. Scott, Anita L. Kozyrskyj

Abstract

Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants. Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score (p = 0.02) and with increased odds of overweight or obesity (p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation (p = 0.2). Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3-4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association.

Twitter Demographics

The data shown below were collected from the profiles of 284 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 18%
Researcher 8 18%
Student > Bachelor 8 18%
Student > Master 6 13%
Unspecified 5 11%
Other 10 22%
Readers by discipline Count As %
Medicine and Dentistry 9 20%
Unspecified 9 20%
Biochemistry, Genetics and Molecular Biology 7 16%
Agricultural and Biological Sciences 4 9%
Psychology 3 7%
Other 13 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1222. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2018.
All research outputs
#2,050
of 12,388,186 outputs
Outputs from CMAJ
#3
of 5,696 outputs
Outputs of similar age
#118
of 262,099 outputs
Outputs of similar age from CMAJ
#1
of 119 outputs
Altmetric has tracked 12,388,186 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,696 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,099 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.